Chemical Safety and SDS Management¶
1. Hazard Classification of Common Reagents¶
| Chemical | GHS Hazard | PPE Required | Storage |
|---|---|---|---|
| TFA | Corrosive (H314), Respiratory (H335) | Acid-resistant gloves, face shield, fume hood | Glass, segregated, ventilated |
| Piperidine | Flammable (H226), Toxic (H301, H311, H331) | Nitrile gloves, goggles, fume hood | Flammable cabinet |
| DMF | Reproductive Hazard (H360) | Nitrile gloves, fume hood | Ventilated, sealed |
| DCM | Carcinogen (H350), Toxic (H331) | Nitrile gloves, fume hood | Flammable cabinet |
| Acetonitrile | Flammable (H225), Toxic (H302, H312, H332) | Nitrile gloves, goggles | Flammable cabinet |
| Diethyl ether | Extremely flammable (H224) | Nitrile gloves, no sparks | Flammable refrigerator |
2. SDS Management¶
| Requirement | Procedure |
|---|---|
| SDS Availability | Hardcopy in chemical storage area + digital on shared drive |
| SDS Review | Updated when new chemical introduced, minimum annually |
| New Chemical Approval | Safety review before purchase |
| Training | Annual chemical safety training for all personnel |
3. Spill Response¶
| Spill Size | Response |
|---|---|
| Small (<100 mL lab) | Use spill kit, absorb, dispose as hazardous waste |
| Large (>100 mL) | Evacuate area, call emergency response |
| TFA spill | Neutralize with sodium bicarbonate, absorb |
| Organic solvent | Absorb with vermiculite, ventilate area |